Wyly Wade

Human trials having 75% success rating for curing leukemia

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Leukemia had invaded his bone marrow and spread like a stain through his lymph nodes; the traditional options, including chemo and radiation, had failed. Walt needed something radically different if he was going to live. And the treatment he’d been given a few days ago was certainly that. Over the past several years, a couple of hundred mice had received it, but Walt was only the seventh adult human. (Six men had preceded him, as well as a six-year-old girl.) The treatment wasn’t a chemo drug, and it wasn’t a vaccine. Instead, doctors at the University of Pennsylvania had tried to make Walt’s own body the drug. In an approach known as gene therapy, they’d taken his own immune cells, modified them to give them new powers, and injected them back into his blood. Walt’s doctors had done things differently than past scientists. Their approach was original and new. And, incredibly, they’d already succeeded in making tumors vanish in a few of the patients who’d come before Walt. Using their custom technology, the Penn physicians had jolted two cancer-riddled men into sudden apparent remission—an outcome dramatic enough to earn mentions on TV news and a write-up in the New York Times. In September 2011, the paper described Penn’s work as “a turning point in the long struggle to develop effective gene therapies against cancer.”


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